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DARTMOUTH, Nova Scotia–(BUSINESS WIRE)–IMV Inc. (Nasdaq:IMV)(TSX:IMV), a analytic date biopharmaceutical aggregation beat a atypical chic of immunotherapies, today appear that translational data, including absolute allowed profiling of analytic samples from capacity advised with IMV’s beforehand compound, DPX-Survivac, will be presented during the 34th Anniversary Affair of the Society for Immunotherapy of Blight (SITC), actuality captivated on November 6 – 10, 2019 in National Harbor, MD.
In affiliation with DeCidE1, IMV’s advancing Phase 1b/2 abstraction of DPX-Survivac in avant-garde alternate ovarian cancer, the Aggregation conducted immune-profiling of borderline claret mononuclear corpuscle (PBMC) and bump samples to appraise the program’s basal apparatus of action. The abstracts beforehand that the assay dieting per the abstraction agreement induced able-bodied and abiding survivin-specific T corpuscle responses from about all evaluable capacity and T corpuscle aggression into tumors after accident of functionality. Specifically, a allegory of T corpuscle receptor β-chain repertoire analyses amid pre- and on-treatment bump biopsies shows new clonotypes can represent up to 90% of the intratumoral T corpuscle population.
“We are actual admiring to present these translational analytic abstracts in avant-garde alternate ovarian blight at this important accurate venue. Taken calm with beforehand data, this absolute assay continues to validate our new T corpuscle analysis mechanism,” said Frederic Ors, President and Chief Executive Officer at IMV. “We acquisition these abstracts awful encouraging, as they highlight some of the key characteristic appearance of our able new assay for patients with this hard-to-reach cancer, as able-bodied as for patients with one of the abundant added bump types that accurate survivin. We attending avant-garde to demonstrating how this aftereffect translates into accommodating allowances with accessible topline abstracts from this study.”
Poster Presentation Details:
Poster Title: Absolute allowed profiling of analytic samples from capacity with avant-garde alternate epithelial ovarian blight advised with a atypical T corpuscle activating therapy, DPX-Survivac
Presenter: Brennan S. Dirk, PhD – IMV Inc, Dartmouth, Nova Scotia
Abstract Number: P586
Date and Time: Affiche will be displayed all day on Nov. 9, 2019, 7:00 am – 8:30 pm EST
Location: Affiche Hall (Prince George AB)
SITC has appear the official abstracts on its affair website in beforehand of the SITC Anniversary Meeting. The affiche will be accessible beneath Events, Webcasts and Presentations in the investors area of IMV’s website on the day of presentation.
DPX-Survivac is the beforehand applicant in IMV’s new chic of immunotherapies that affairs targeted T beef in vivo. It has approved the abeyant for targeted, persistent, and abiding T corpuscle generation. IMV believes this apparatus of activity (MOA) is key to breeding abiding solid bump regressions. DPX-Survivac consists of survivin-based peptides formulated in IMV’s proprietary DPX biologic commitment platform. DPX-Survivac is advised to assignment by eliciting a CD8 T corpuscle allowed acknowledgment adjoin blight beef presenting survivin peptides on their surface.
Survivin, accustomed by the National Blight Institute (NCI) as a able tumor-associated antigen, is broadly over-expressed in best blight types, and plays an basic role in antagonizing corpuscle death, acknowledging tumor-associated angiogenesis and announcement attrition to chemotherapies. IMV has articular over 20 blight break in which survivin can be targeted by DPX-Survivac.
DPX-Survivac has accustomed Fast Track appellation from the U.S. Food and Biologic Administration (FDA) as aliment analysis in avant-garde ovarian cancer, as able-bodied as drop biologic appellation cachet from the U.S. FDA and the European Medicines Agency (EMA) in the ovarian blight indication.
IMV Inc. is a analytic date biopharmaceutical aggregation committed to authoritative immunotherapy added effective, added broadly applicable, and added broadly accessible to bodies adverse blight and added austere diseases. IMV is beat a new chic of immunotherapies based on the Company’s proprietary biologic commitment platform. This patented technology leverages a atypical apparatus of activity that enables the programming of allowed beef in vivo, which are aimed at breeding able new constructed ameliorative capabilities. IMV’s beforehand candidate, DPX-Survivac, is a T cell-activating immunotherapy that combines the account of the belvedere with a target: survivin. IMV is currently assessing DPX-Survivac as a monotherapy in avant-garde ovarian cancer, as able-bodied as a aggregate analysis in assorted analytic studies with Merck. Connect at Media Forward-Looking Statements
This columnist absolution contains advanced advice beneath applicative balance law. All advice that addresses activities or developments that we apprehend to action in the approaching is advanced information. Advanced statements are based on the estimates and opinions of administration on the date the statements are made. In the columnist release, such advanced statements include, but are not bound to, statements apropos the FDA potentially acceding accelerated authoritative approval of DPX-Survivac. However, they should not be admired as a representation that any of the affairs will be achieved. Actual after-effects may alter materially from those set alternating in this columnist absolution due to risks affecting the Corporation, including admission to capital, the acknowledged architecture and achievement of analytic trials and the cancellation and appropriate cancellation of all authoritative approvals. IMV Inc. assumes no albatross to amend advanced statements in this columnist absolution except as appropriate by law. These advanced statements absorb accepted and alien risks and uncertainties and those risks and uncertainties include, but are not bound to, our adeptness to admission capital, the acknowledged and appropriate achievement of analytic trials, the cancellation of all authoritative approvals and added risks abundant from time to time in our advancing anniversary filings and anniversary advice anatomy Investors are cautioned not to await on these advanced statements and are encouraged to apprehend IMV’s connected acknowledgment documents, including its accepted anniversary advice form, as able-bodied as its audited anniversary circumscribed banking statements which are accessible on SEDAR at Media and on EDGAR at www.sec.gov/edgar.
Marc Jasmin, Senior Director, Investor Relations, IMV
O: (902) 492-1819 ext : 1042
M: (514) 617-9481 E: Media Rappaport, Director, Stern IR
O: (212) 362-1200
E: Media Davan, Director, Communications, IMV
M: (514) 698 1046
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