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During the aboriginal appearance of recruitment, the majority (70%) of women were age-old 50-64 years, with 23% age-old 65-73 years and 7% adolescent than 50 years. Best women were white British/Irish (91.0%), 1.3% were Asian, 4.0% had added ethnicities and 3.7% did not address ethnicity. In the additional phase, a beyond admeasurement of adolescent women were recruited: 43% were age-old 46-49 years and 49% age-old 50-54 years. The majority were afresh white British/Irish (89.0%) but there were proportionally added Asian women (3.3%) than in the aboriginal phase. Overall, about the aforementioned admeasurement recruited in anniversary appearance declared a alternative to be abreast of their accident (94.5% vs 95.0%).



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In complete 57,902 women were recruited to PROCAS; 906 of whom had ahead developed breast cancer. A complete of 891 (1.54%) women self-identified on their questionnaires as actuality Asian or Asian British (12 with antecedent breast cancer), with 52,639 (90.9%) who articular themselves as white British or Irish (830 with antecedent breast cancer). Proportional uptake of Asian women to PROCAS compared with the afflicted Asian women citizenry in Greater Manchester is apparent in Table 1.

Overall access to PROCAS amidst Asian women was lower than would be accepted in the arrive citizenry as a whole. The about uptake alone from almost 1 in 3 for Asian women in those age-old 46-49 years to alone 1 in 6 age-old ≥65 years.



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After excluding those with antecedent breast blight and not age-old 46-73 years at entry, 879 Asian women and 51,779 white British/Irish women remained. Table 2 shows the age standardised accident agency arbitrary at access for women self-identified to be white British/Irish or Asian in the PROCAS study.

There were a cardinal of differences in the accident of accident factors that were reflected by a lower accident appraisal for Asian women than white British/Irish women (mean 10 year accident 2.67% vs 3.07%). A greater admeasurement of Asian women fell into the low-risk (< 2% 10-year risk) accumulation (32.6% vs 18.9%) and a lower admeasurement into the animated accident (≥5% 10 year) accumulation (6.7% vs 9.9%).



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Asian women had a afterwards age at menarche than white British/Irish women and were added acceptable to be post-menopausal with an beforehand age at menopause. On average, Asian women were beneath adipose (mean BMI 26.5 vs 27.5 kg/m2) and beneath (mean 1.57 vs 1.62 m) than white British/Irish women. Asian women were beneath acceptable to be nulliparous (9.7% vs 13.0%) and had beyond families (26.7% had four or added accouchement compared with 10.0%). In those with children, the age at aboriginal adolescent was similar, as was the admeasurement with a aboriginal adolescent age-old < 17 years. Asian women were beneath acceptable to accept a ancestors history of breast blight (10.4% vs 12.1% had one or added afflicted first-degree relatives), and abundant beneath acceptable to accept anytime acclimated hormone assay (20.3% vs 38.3%).

There were some differences in accident factors that are not included in the Tyrer-Cuzick accident appraisal model. Alcohol use was essentially lower in Asian women than white British/Irish women (18.8% vs 73.0%). Asian women acquired an complete 4% added weight back age 20 years than white British/Irish women, and they were beneath acceptable to exercise (49.9% vs 72.2%). There was some affirmation to advance that mammographic body in Asian women was animated compared to white British/Irish women, but the complete aberration was baby afterwards acclimation for age and BMI (1.8% greater, 95%CI 0.04 to 3.3%).

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Cohort trends in accident factors that are accepted to access breast blight accident were apparent in both the Asian and white British/Irish populations (Table 3).

One of the better changes was in the cardinal of accouchement and age at bearing of aboriginal child. In the Asian group, there was a addiction for the earlier accomplice to accept accustomed bearing afterwards and to accept beneath accouchement (31.1% in accomplice built-in afore 1950 had four or added accouchement compared with 22.1% built-in ≥1960). There was additionally a acceleration in nulliparity ante (6.3% to 13.1%). Agnate trends were apparent for white British/Irish women. Changes in abundance of concrete action were additionally observed; adolescent Asian and white British/Irish women were beneath acceptable to exercise. Alcohol use was best accustomed for white British/Irish women built-in afterwards 1950. Due to the ample sample size, abounding of the trends of added accident factors in white British/Irish women were statistically significant, but some differences were not large.

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Rates of breast blight by age accumulation are presented in Table 4. Age standardised ante were lower in Asian women. Although this is in band with expectations from the assay of accident factors, we abridgement statistical ability to ascertain differences.

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